We live in a society with epidemic rates of obesity, diabetes and heart disease. This suggests there is something fundamentally wrong with our lifestyle.
We all need to reduce our intake of meat and dairy products, enjoy more fresh fruit & vegetables, and take time out for relaxation and exercise.
In particular, we need to explore ketogenic diets that might actually protect against some features of the ageing process.
One element that can profoundly accelerate the ageing process is stress. The effects of prolonged high cortisol levels can have a profound effect on ageing.
Assessing telomere length may be a wake-up call to re-evaluate our lifestyles....Serial Telomere measurements may enable us to confirm beneficial intervention to the ageing process.
To date health screening has been a major commitment. The premise is to identify cardiovascular or malignant disease at an early stage in order to try and improve outcome........only for 5 years later dementia to rear its ugly head......Wouldn't it make far more sense to delay the entire ageing process.....IN EFFECT STAY YOUNG FOR LONGER
DNA and Telomere length
Within each cell of the body the DNA is supported by telomeres. If DNA is akin to a shoelace, telomeres are akin to the plastic capping at the ends.
Like shoe lace caps they stop the DNA fraying. With age the telomeres shorten and eventually this leads to DNA "fraying" and eventually cell death.
The Nobel prize winning (2009) science demonstrated telomere length is a validated assay for biological age and what is exciting it can be used as a marker of the effects/ benefits of agents aimed at extending life by reducing biological age.
The good news is we can measure telomer length.....THE EVEN BETTER NEWS IS WE ONLY NEED A SIMPLE FINGER PRICK SAMPLE TO ASSAY
The quest for the Elixir of Life is as old as mankind.....and on that score we cannot promise to deliver. However, interest is mounting, entire university departments are now devoted to anti-ageing medicines, academies of anti-ageing medicines are emerging throughout the Western World, and pharmaceutical companies are embracing the quest to investigate anti-ageing medications.
The notoriously conservative Food & Drugs Administration (FDA) in the USA have recently sanctioned studies looking at drugs specifically for their anti-ageing potential. 2 drugs are under investigation Metformin (The TAME Study) and Rapamycin. Both have been shown to significantly extend life expectancy in animal models.
Nicotinamide mononucleotide (NMN) is a compound NASA is particularly interested in studying for use in astronauts to counteract the effects of cosmic radiation. It has been shown to slow the ageing process in animal models and a human trial is planned in Japan. It activates a gene called sirtuin which is able to silence genes promoting aging.
Nicotinamide Adenine Dinucleotide (NAD+) has been shown in a landmark study by Harvard researchers to make the cells of 2 year old mice look like 6 month old mice. It promotes sirtuin gene activation , enhances the efficiency of mitochondria (the power house of the cell), promotes insulin sensitivity to optimize healthy blood sugar levels, enhances cognitive health and repairs DNA.
Ginkgo biloba extract (EGb761) reduces endothelial progenitor cell senescence through augmentation of telomerase activity. Telomerase activation may play a key part in life extension models.
PQQ (pyrroloquinolone quinone) +/- Co Q10 is showing promise in mitochondrial reactivation. Enhancing the power house activity of mitochondria
Metformin enhances the activity of adenosine monophosphate-activated protein kinase (AMPK) which mimics the beneficial effect of calorie restriction.
Resveratrol has been extensively advocated for its profound anti-oxidative effects
AS YOU CAN TELL THE QUEST FOR EFFECTIVE ANTIAGEING MEDICATIONS IS HOTTING UP!